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 1 
 on: Yesterday at 07:09:47 AM 
Started by Dutch - Last post by Dutch
In a previous post I have mentioned that There are 2 major timeframes coming up on the timelines in the HDDesign material: the Grand Cross orbital position around June 26, 2010 and ‘Contact’ , around August 23, 2010. Both timeframes are identified and described in the HDDesign material only.

I have to emphasize that the Grand Cross of orbital positions in the HDDesign material is something else than a Grand Cross of Planetary alignments. The Grand Cross of orbital positions in the HDDesign material creates a Grand Cross with specific orbital positions of Earth on its orbit around the sun . In my native language ( Dutch ) the word ‘cross’ is also used to express a ‘crucifix’ and the Grand Cross in the HDDesign is just like that: a crucifix.

As everything else in the HDDesign material, the Grand Cross of orbital positions initially emerged by an intuitive thought and the follow up of the synchronicities that occurred.
The astrological Grand Cross planetary alignment of August 18, 1999 ( 'as above' ) was the first 'marker' on Earth's orbit in order to determine a Grand Cross ( crucifix) as created with Earth's orbital positions ( 'so below' ) The second 'marker' was the planetary alignment of May 5, 2000 so the 2 other orbital positions of the Grand Cross ( crucifix ) on Earth's orbit could be calculated: December 26 ( Sumatra quake /Tsunami ) and June 26.
The info can be reviewed is a separate thread dedicated to the orbital Grand Cross in the HDDesign material here: 
http://hddesign.forumup.nl/viewtopic.php?t=413&mforum=hddesign

So with the December 26, 2004 massive Earthquake in Sumatra ( 9+) and the Tsunami that followed,  3 orbital positions of the crucifix were marked on Earth’s orbit and I expected that the last orbital position of the crucifix should be confirmed too: around June 26.

Earth’s orbital position around June 26, 2010 was according to the HDDesign material ‘on top’ of the Grand Cross ( crucifix, so below) and was marked by a powerful alignment of seven planets in a Grand Cross formation, including a partial lunar eclipse!( as above)
( see for instance: Capricorn Full Moon eclipse June 26, complete with Grand Cross
Read more: http://blog.beliefnet.com/astrologicalmusings/2010/06/capricorn-full-moon-eclipse-ju.html#ixzz0sVj8pN6o )

The 9+ December 26, 2004 Sumatra Quake / Tsunami is herewith firmly marked as one of the most profound events in the Design of the times we live in. I remember that  back in 2004 prior to the Venus Transit, I talked about an expected  Hyper- Dimensionally initiated ‘charge’ up that would be triggered by the Venus Transit and would become apparent on Earth in the leading Hyper Dimensional Octahedron area : Indonesia. Around the Venus Transit of June 8, 2004 the volcanic activity increased significantly in the Indonesian area and the ‘charge up’ eventually culminated with the Sumatra quake/ tsunami.

There’s something else with the Sumatra quake/tsunami, which was initially triggered by the Venus Transit. The December 26, 2004 Sumatra quake/tsunami happened with Venus on the same orbital position as during the end of the Mayan Long count in December 2012, exactly 13 Venus years apart or exactly similar as the timeframe between the 2 Venus Transits of our times: June 8, 2004 and June 6, 2012! ( ergo: timeframe between Venus Transits is similar as between the Sumatra quake and the end of the Mayan Calendar).

Back to the orbital position of the Grand Cross around June 26 again. I wrote that I was busy at work while I suddenly got this idea to consider these 2 major timeframes, grand cross June 26, 2010 and August 23, 2010 ‘Contact’,  to be the 2 Pi points on a timeline, in the very same way as expressed with the ‘Deep Impact / Epoxi communication ’as explained in the HDDesign material.  This Pi based Design was first discovered in the HDDesign material in relation to the ‘communication’ that took place with the spacecraft Deep Impact/ Epoxi ( you can review or reread it if you like ). While an actual planetary alignment in itself is a already a strong confirmation of the given hidden underlying Design, I did expected at least a second confirmation during this years orbital position of the Grand cross.

And as an ‘in the face’  confirmation its spacecraft Deep Impact/Epoxi that made one final flyby of Earth during the Grand Cross orbital position around June 26, 2010, getting a gravity assist to help propel the spacecraft towards a meetup with comet Hartley 2 this fall:
Deep Impact / Epoxi Spacecraft to Make Final Flyby of Earth
http://www.universetoday.com/2010/06/25/spacecraft-to-make-final-flyby-of-earth/

The first time spacecraft Deep Impact made an Earth fly by, end of December 2007, it was about 911 days after Deep Impact on comet Temple I and therefore creating a Hyper Dimensional Tetrahedron according the described Platonic Solid based elements in the HDDesign material.
And again 911 days later, again creating a Hyper Dimensional Tetrahedron, Deep Impact/Epoxi made an Earth fly by again during Grand Cross around June 26, 2010 !! Not only confirming the significance of the Grand Cross, but also confirming August 23, 2010 with ‘contact’ as underlying theme.

But there’s more. This year orbital position of the Grand Cross also creates a ( geometrical Platonic Solid based ) Hyper Dimensional Tetrahedron with the end of the Mayan calendar!!

Plato………

Watch this video, the maker has used several items directly taken from the HDDesign material :
Hypergeometry, Astrology and the spaces inbetweenLQ | HQ


With a previous post I have introduced Edgar Alan Poe’s ‘Eureka’ and the actual earthquake in Eureka as part of the ‘communication’ that is taking place. You can read about Poe’s Eureka in my previous post or here:
http://en.wikipedia.org/wiki/Eureka:_A_Prose_Poem

As a nice synchronicity, Dr Kennedy, a science historian in Manchester claims to have deciphered secret messages hidden in the ancient writings of the philosopher Plato.
Like all great discoveries, Dr Kennedy said his own Eureka moment was partly due to 'luck.'
By unravelling Plato's 'hidden' messages, Dr Kennedy believes he has thrown a new light on the origins of science, mathematics, music, and philosophy.
Read on:
http://news.bbc.co.uk/local/manchester/hi/people_and_places/newsid_8773000/8773564.stm

Its not ‘luck’, its because the time is right. So we have this HD Tetrahedron, geometrically  based on one of Plato’s Solid , connecting the Grand Cross of June 26, 2010 and the end of the Mayan calendar. As a regular reader of the HDDesign forum you might have noticed that I have been monitoring crop circles since e few weeks.



A crop circle thought to be inspired by a formula acclaimed as the most beautiful in all mathematics has appeared on a hillside in Wiltshire.
Experts say that the design may be connected to Euler's Identity, a complex formula devised by the 18th Century Swiss mathematician Leonhard Euler.

"This is one of the most profound and complicated equations of the past 2,000 years, and we think the crop circle is some form of visual translation."

The Wilton Windmill pattern is the latest in a long line of mathematical crop circles in Britain. In 2008 a coded image representing the first 10 digits of pi was discovered in a barley field in Wiltshire.  ( Dutch: which made me discover the Pi based communication with this spacecraft Deep Impact/Epoxi )

Euler's Identity is admired by mathematicians for linking several fundamental mathematical constants.

Keith Devlin, professor of mathematics at Stanford University in California, said that the formula "reaches down into the very depths of existence ... like a Shakespearean sonnet that captures the very essence of love."
http://www.telegraph.co.uk/science/science-news/7760079/Crop-circle-inspired-by-most-beautiful-formula-in-mathematics-appears-in-Wiltshire.html

There’s a German called Werner Johannes Neuner who has deciphered this cropcircle and he comes up with the very same 2 dates as determined here in the HDDesign material: Grand cross June 26, 2010 and the end of the Mayan calendar. You can find his work here in his native language:
http://www.meinthema.com/de/wernerneuner/News/W9News

But there’s already a translation available, let’s see what Werner has to tell:

In english:
"On May 22 a crop Circle appeared near the windmill of Wilton in Wiltshire, South of England – a crop circle with an encoded message. This crop circle speaks of a profound paradigm shift, a reverse of polarity.
It alludes to two dates: The Grand Cross on June 26 2010 and December 21, 2012.
It contains a powerful warning, speaks of a global crisis and at the same time it shows the solution.
On June 26, 2010, there is an extraordinary planetary constellation, a Grand Cross. According to the message of the crop circle, the sun creates a new room, a healing room, a new field of consciousness on that day.
The sun unites two poles, merging them to a unity on June 26. This merging of polarities leads to a short-circuit, or in other words, a cosmic orgasm due to which a new room will enfold. This new room is a gift, because in this new room what seemed devoid of meaning all of sudden makes sense again. What enfolds is a new, corrected reality, shifted in phase!
According to the message of the crop circle this new room can be accessed by everyone through the power of consciousness.
If LOVE succeeds on earth, and be it for only a few hours in just one person or in just one loving couple, this experience of LOVE will leave a trace in this newly opening room, a trace which is eternal and will remain active forever. A shining trace, a trace of love, which will remain visible far beyond earth atmosphere. Each experience of love and every experience of peace will stimulate this room, fill and adorn it. The power of this room is going to grow exponentially. The songs of the Healed Matrix are the hymns which will fill this room!
Each person who dares to leave behind the matrix of power and violence, everyone who is not afraid of letting go old belief systems but live instead in harmony with Mother Earth and ALL that IS, will be able to access this room. Each person will receive healing impulses from this room through his consciousness and heart and will give in return his/her healing experience back to this room.
What we find in this room will exist within ourselves and outside of us. It is a Secret of the Universe, that what is being formed outside can be accessed from within; you find it in your own sacred inner space, your personal centre.
And once this Healing Matrix in this newly created Healing Room will be powerful enough, the matrix of fear will dissolve and the Healing Matrix will expand.
This is the Plan of the Star Master and the Planetary Beings.
This Healing Room is less than an atom in distance from us.
This Healing Room is in our own Sacred Space Centre when we are in unison with ourselves, in unison with Mother Earth and in unison with ALL that IS.
Werner Johannes Neuner describes the process of decodification of the message of the Crop Circle of Wilton in detail and all the information is available in German at this link:
http://www.meinthema.com/de/wernerneuner/News/W9News
He is looking forward to entering this Sacred Room together with all of us,
In the Light of Unity "
Werner Johannes Neuner and Sonja Myriel, who translated this message

end of quote.

Its true that I also expected events expressing the underlying themes ‘exit of Sun King’ and ‘San Andreas fault’ for around the June 26 orbital position of the Grand Cross, although I couldn’t know for which year so I stated in advance that I expect expressions related to these themes around June 26, 2010, June 26, 2011 or June 26, 2012.

In case of an Hyper Dimensionally initiated Earth change event like a (big)  earthquake,  we first see a Hyper Dimensional ‘inwelling’ , becoming apparent in our 3D reality above 60 degrees latitude ( see Enterprisemission’s ‘Hyper Dimensional Physics’ for details, I can provide them too), followed by an ‘outwelling’ sometime later. I have no idea how long it could take ( continued monitoring should shine a light on it I suppose. ). Perhaps the 4.8 Southern Alaskan earthquake at 62 North during the Grand Cross was such a 3D counterpart of a HD ‘inwelling’  and is the ‘outwelling’ yet to come, I don’t know. The Sumatra quake was more than half a year after the Venus Transit so I will keep on monitor it.

‘Contact’ is ongoing and HDDesign will continue to unveil it.

Keep an eye on the timelines ( ‘Contact’ around august 23 ) :
Q3 2010 timeline, July - August - September 2010
http://hddesign.forumup.nl/viewtopic.php?t=445&mforum=hddesign

 2 
 on: Yesterday at 07:08:22 AM 
Started by Summer Wine - Last post by Summer Wine
The truth of the matter is that the "giant pig" that congress passed off as healthcare reform is becoming more and more apparent as another government boondoggle. I have lost all my ideas that government can do anything right. Government is not our friend and they are clueless and blind. They have absolutely no idea what it is like to live in the real world cause they sure as hell don't live in our world. They live in an artsy fartsy castle in the clouds. I am going to be losing my health insurance now thank you Obama. Little governments all over the country are falling apart. The insurance giants are simply raising rates to astronomical rates that most businesses and local governments can't pay, and we the people the taxpayers can't pay!

I am deeply, sorely, disappointed in the  hope that I had for change!

http://www.lewrockwell.com/north/north828.html
Health Care and Detroit: Killed By Government

 To understand what is going to happen to America's health care delivery system, we must first understand what has happened to Detroit.

Detroit is dying. Yes, I know that there are lots of books on "The Death of. . . ." That word sells books. But Detroit really is dying. It is the first metropolis in the United States to be facing extinction. We have never seen anything like this in American history. It is happening under our noses, but the media refuse to discuss it. To do so would be politically incorrect. Two factors tell us that Detroit is dying. The first is the departure of 900,000 people – over half the city's population – since 1950. It peaked at 1.8 million in 1950. It is down to about 900,000 today.

In 1994, the median sales price of a house in Detroit was about $41,000. The housing bubble pushed it up to about $98,000 in 2003. In March 2009, the price was $13,600. Today, the price is $7,000. Check the price chart.

There has never been a collapse of residential real estate values of this magnitude in peacetime history, anywhere. Detroit is dying.

We are unfamiliar with anything like this. The media are silent. The Powers That Be are not interested in reporting on this, because readers might ask the obvious question: "How did this happen?" Obvious questions tend to lead to obvious answers.

Detroit has been killed by flight out of the city. The 2008 Clint Eastwood movie, Gran Torino dealt with this problem. Eastwood plays an 80-something Korean War veteran who will not leave the neighborhood. His children keep bugging him to sell and move into a retirement home. He will not hear of it. He is alienated from them and from his immigrant neighbors: Hmong refugees from South Vietnam. The Hmong have trouble with the Blacks. Every group is essentially trapped in a neighborhood, with the gangs running the show.

There is no surge of buyers to take advantage of fabulously low prices in Detroit. Can you imagine buying a home for cash for $13,600 in 2009 – a house that had sold for $98,000 six years earlier – and losing half your money? It's incredible.

The Wall Street Journal recently ran one of the most creative stories I have seen in years. The journalist told the story of the history of a 5-bedroom home in Detroit, from the land purchase to its recent sale. It was built by one of the most influential man you have never heard of, Clarence Avery. Avery was on the Ford Motor Company team that conceived of implementing an assembly line for Ford's factory. He copied the idea from a hog-slaughtering operation.

His home was a very nice home for the time. The journalist located his daughter, now age 91. She said that she always thought the home was the best home she ever lived in.

As recently as 2005, the home sold for $250,000. It was purchased by a woman who was lent $200,000 to buy it. It was financed by a subprime loan. The asking price was $189,000. Where the other $61,000 went, the woman has no idea. She defaulted.

The deteriorating house was bought by a Christian organization that is renovating it. The house sold for $10,000.

This is simply inconceivable to anyone who is unfamiliar with Detroit since 2005. Nothing like this has ever happened. How can we conceive of a lender lending $200,000 to a woman to buy a $250,000 home offered at $189,000? How can we conceive of a fall in price from $250,000 to $10,000?

This is the sign of a dying city. This does not happen in a normal environment. Even with the mania created by Fannie Mae and Freddie Mac, in conjunction with Alan Greenspan's Federal Reserve, nothing like this has happened anywhere else.

If you had predicted anything like this in 2005, you would have been dismissed as a crackpot on crack. You would not have been taken seriously by anyone. Yet it has happened.

The city planners, the Federal government's subsidy defenders, and the welfare state aficionados are all discreetly silent about Detroit.

The city funds its schools with property taxes. Property taxes have collapsed as sources of revenue. An honest property tax system will generate less than ten cents on the 2003 dollar.

Last week, the school board announced the closing of one-quarter of Detroit's schools. The city is out of money. The central agency of propaganda by the government is in the process of closing up shop. This is not "anti-business as usual." This is collapse. The American public does not perceive what is happening in Detroit.

When a city simply shuts down from the effects of government mismanagement, the media say nothing. Detroit has become the poster child of government regulation, welfare systems, and a population that has given up hope.

The media say nothing because they are caught in a dilemma. If they say that the local government's welfare programs are not really to blame, what does that leave? The unmentionable issue: 82% of the city is Black. So, that means blaming white employers, who discriminate, despite 40 years of Federal anti-discrimination laws. But the main non-employers today are the region's auto companies, and two of the three are partially owned by the U.S. government. One – GM – is mainly owned by the retirement fund of the United Auto Workers. So, the media are not about to blame the auto companies – not now.

That leaves that other politically incorrect issue: the rate of illegitimacy, which is in the 80% range. That social phenomenon represents a moral collapse, but the participants were all educated by the tax-funded schools.

Who ya gonna blame?

The media pundits cannot decide, so they simply ignore the collapse. "Detroit? Never heard of it."

The lesson of Detroit is this: the experts do not see a collapse coming. They assume that next year will be like today, give or take 3%. They do not believe that anything as complex as a city can collapse. So, they believe that things will continue, as they always have. Taxes need not be cut. Spending need not be cut. Schools should be allowed to educate. Tax-funded welfare programs should be increased. When it comes to tax revenues, "there's always more where that came from."

And then, overnight, the system collapses. The assumptions were wrong. Real estate prices collapse, indicating an irreversible flight of capital from the city. The ability of the government to collect taxes collapses.

OBAMACARE

This brings me to the other subject: the health care law. It is not law yet, but it soon will be.

I know what is going to happen.

    1. Cost overruns
    2. Fraud
    3. Additional coverage extended to groups
    4. Rising deficits in the program
    5. Lower payments to physicians
    6. Lower payments to hospitals
    7. Delays in payments
    8. Rising taxes on the rich
    9. Rationing by doctors, hospitals, government
    10. Delays in treatment
    11. More HMO care: assembly line medicine
    12. A search for scapegoats

In 1977, I was involved in an early warning operation. Three teams of physicians and economists toured the country. We hit 30 cities in two weeks. We warned physicians in poorly attended meetings that something like Obamacare was coming. It has now arrived. The physicians we spoke to are mostly retired. They saw some of this happen on a minor scale, but they escaped.

I spoke about the percentage of the GDP (then GNP) devoted to heath care: about 7%. Today, it is 15%. Medicare and Medicaid have increased costs. The care is no better. Except for technology, it is arguably worse.

Obamacare will lead to an expansion of these forms of medicine:

    1. Concierge
    2. Wal-Mart
    3. ER
    4. HMO
    5. Mexican

CONCIERGE. The rich and very rich hire their own physicians. They pay top dollar. The physicians do not take third-party payments, either from the government or insurance companies. They are independent practitioners. They make house calls. The houses they call on are very large.

For the upper middle class, there are fee-for-service physicians. They take no third-party payments. They do not make house calls.

WAL-MART. These are the walk-in clinics. They are price competitive. They treat minor ailments. They sell services on a one-time basis. They take credit cards. They may or may not cater to the Medicare crowd. They are assembly-line clinics. There are no major surgeries or other high-cost, high-risk services.

ER. Large hospital emergency rooms are mandated by law. The poor get treated there. In a life-and-death emergency, they work. People who would otherwise die in a couple of hours are saved. For walk-in patients, the ERs ration by time. Patients demonstrate their patience.

HMO. This style of medicine is efficient. It cuts costs by cutting services and cutting time. You see the physician on duty. You may not have seen him before. His job is to get you in and out as fast as possible. Time is monitored by the company. Computers make this easy.

MEXICAN. This is off-shore medicine. In Canada, when you can't get treated for months or years, you come to the United States and pay. This will not be possible for Canadians much longer, except for rich ones. Mexico will serve upper middle-class Americans as the USA has served Canadians.

It is possible to get very good surgical care in Asia and Latin America. You have to know who the good practitioners are. Asian hospitals sell for 25% the same level of services. There is less regulation there. Plane fares are cheap. A stay in a hotel is cheap.

There will be entrepreneurs who set up Websites off-shore that direct Americans to practitioners abroad. The Web allows this sort of advertising.

Physicians who practice alone or in small limited liability corporations will find that they cannot compete under the new payment system. Assembly-line medicine will replace the traditional doctor-patient relationship.

TRAPPED

Most physicians are trapped. They cannot sell their practices. The price of practices has been dropping.

Foreign-trained physicians who can pass the U.S. tests are coming to America. They are competitive.

Technical Services that can be digitized are being outsourced to India and other Asian nations.

Young American physicians begin with a lot of debt. They need income fast. They will be hired by the HMOs and clinics. They will not reach the salary level of this generation of physicians. They will be upper-middle-class income-earners.

There will be specialists, of course. Plastic surgeons who specialize in making rich women better looking will not be part of the new system. They will be able to do well. But for the typical practitioner, his career options have been dramatically restricted by the new law.

I think most physicians will stick it out until they retire at age 67. They owe money. They need the income. The law's most restrictive provisions will not kick in until 2014. They will adjust.

Residents of Detroit also adjusted. Then, without warning, the economy changed. Those who were still living in the city saw their capital disappear.

People put up with the devils they know. They do not look for a lifeboat when they hear the ship scrape the iceberg. They assume that it will be business as usual.

Then, one fine day, it isn't.

CONCLUSION

You had better decide which kind of medical care you can live with. Then you had better locate a practitioner soon. This is especially true if you want a fee-for-service physician. People with money will go to them. They are already hard to find. They charge more. It's not easy to become a patient. They are booked up.

If you have an existing physician, do what you can to become an above-average patient.

You had better start getting into shape. You can no longer afford to be vulnerable to the diseases and afflictions of a flabby lifestyle. ObamaCare has changed the risk-reward ratio. Risk has just gone up. It will continue to go up.

There will be no roll-back of this law. It is going to be enforced for as long as the U.S. government has money.

That may not be as long as Obama thinks.



 3 
 on: July 01, 2010, 11:52:52 PM 
Started by Summer Wine - Last post by chi
 angel  thumbs up as healing continues.

 4 
 on: June 30, 2010, 01:47:59 PM 
Started by Summer Wine - Last post by Summer Wine
http://www.physorg.com/news196943667.html

 (PhysOrg.com) -- A science historian at The University of Manchester has cracked "The Plato Code" - the long disputed secret messages hidden in the great philosopher's writings.

Plato was the Einstein of Greece's Golden Age and his work founded Western culture and science. Dr Jay Kennedy's findings are set to revolutionise the history of the origins of Western thought.

Dr Kennedy, whose findings are published in the leading US journal Apeiron, reveals that Plato used a regular pattern of symbols, inherited from the ancient followers of Pythagoras, to give his books a musical structure. A century earlier, Pythagoras had declared that the planets and stars made an inaudible music, a 'harmony of the spheres'. Plato imitated this hidden music in his books.

The hidden codes show that Plato anticipated the Scientific Revolution 2,000 years before Isaac Newton, discovering its most important idea - the book of nature is written in the language of mathematics. The decoded messages also open up a surprising way to unite science and religion. The awe and beauty we feel in nature, Plato says, shows that it is divine; discovering the scientific order of nature is getting closer to God. This could transform today's culture wars between science and religion.

 5 
 on: June 29, 2010, 04:04:10 PM 
Started by Summer Wine - Last post by Valentine
Wow, that's intense.  I don't get her, and I don't get her appeal. 

 6 
 on: June 29, 2010, 04:01:14 PM 
Started by Summer Wine - Last post by Valentine
It's always nice to see research that supports something one has determined to be true intuitively. 

 7 
 on: June 29, 2010, 03:41:32 PM 
Started by Summer Wine - Last post by Valentine
 love6

 8 
 on: June 29, 2010, 07:01:50 AM 
Started by Summer Wine - Last post by Summer Wine
http://movies.yahoo.com/feature/movie-talk-new-trailer-marks-the-beginning-of-the-end-for-the-harry-potter-movies.html

The "Harry Potter" film franchise is going out with a bang. Several bangs, from the looks of it.

The first trailer for "Harry Potter and the Deathly Hallows" premiered Monday afternoon, and from all appearances this will be darker and more explosive than any of the previous movies. There's so much action, in fact, it couldn't be contained in one movie. Take a look at the preview now:


 9 
 on: June 29, 2010, 06:57:36 AM 
Started by Summer Wine - Last post by Summer Wine
http://www.sciencenews.org/view/generic/id/60568/title/Neutrino_experiments_sow_seeds_of_possible_revolution_

Neutrinos are the big nothings of subatomic physics. Nearly massless and lacking an electric charge, these ghostly particles interact so weakly with other types of matter that more than 50 trillion of them pass unimpeded through a person’s body each second.

Yet recent preliminary findings from two experiments hint that neutrinos may be opening a window on a hidden world of subatomic particles and forces.

The findings from both experiments have relatively large margins of error, so they could end up being statistical flukes. But so far the results, announced June 14 at the Neutrinos 2010 conference in Athens, indicate that neutrinos and their antiparticle counterparts, antineutrinos, are not the nearly exact mirror images of each other that current physics supposes them to be.

 10 
 on: June 29, 2010, 06:48:54 AM 
Started by Summer Wine - Last post by Summer Wine
http://well.blogs.nytimes.com/2010/06/16/phys-ed-a-workout-for-your-bloodstream/

What does exercise do to your body? It may seem as if science, medicine and common sense answered that question long ago. But in fact, the precise mechanisms by which exercise alters your body — at a deep, molecular level — remain poorly understood. A number of analyses of the effect that exercise has on heart disease, for instance, have concluded that working out lessens a person’s chances of developing heart problems far more than scientists can account for. They understand the physiological reasons for about 60 percent of the reduced risk. The rest is a mysterious if welcome bonus.

But a new study  that gauged the metabolic effects of exercise may significantly advance our understanding of what’s going on inside a body in motion. During the experiment, scientists actually saw how much being fit changes your ability to incinerate fat, moderate blood sugar and otherwise function well. They also uncovered proof, at once inspiring and cautionary, of just how complicated and pervasive exercise’s consequences are. http://www.ncbi.nlm.nih.gov/pubmed/20505214

In the experiment, published late last month in Science Translational Medicine, researchers from Harvard University and other institutions relied on a mass spectrometer to enumerate specific molecules in the bloodstreams of people who’d been exercising. The molecules were metabolites, which drive or are the byproduct of metabolic changes in the body. Metabolism is, of course, the chemical process of keeping yourself alive. All of the biochemical processes that feed and nurture cells constitute your metabolism. What the researchers wanted to know is, how does your metabolism change during and after exercise?

For the work, the scientists drew blood from a group of normal, healthy adults, as well as from a separate group who’d been referred for exercise testing because of shortness of breath or suspected coronary-artery disease. This group was relatively unfit. Each of the groups was told to exercise for about 10 minutes on a treadmill or a stationary bicycle, then had more blood drawn. Finally, the scientists also examined blood samples from a group of runners who had finished the 2006 Boston Marathon.

What they found was that after 10 minutes of treadmill jogging or stationary-bicycle riding, the healthy adults showed enormous changes in the metabolites within their bloodstream, as did the less-fit group, although to a lesser degree. In particular, certain metabolites associated with fat burning were elevated. The fit adults showed increases of almost 100 percent in many of these molecules. The less-fit group had increases in those same metabolites of about 50 percent. As for the marathoners, their blood contained up to 10 times more of the fat-burning markers.

These findings suggest that exercise has both “acute and cumulative” effects on your body’s ability to use and burn fat, says Gregory Lewis, a cardiologist at Massachusetts General Hospital in Boston and an author of the study. After only 10 minutes of exercise, even the least fit showed evidence that their bodies were burning fat; the more fit, the more metabolic evidence of fat burning.

The researchers then took a number of the metabolites that had been elevated by exercise and infused them into mouse muscle cells in a laboratory dish. Almost immediately, the metabolites, in combination (but not individually) ignited a reaction that resulted in increased expression of a gene involved in cholesterol and blood-sugar regulation. In other words, the metabolites weren’t just marking activity that was happening elsewhere in the body; they also may have been sparking some of that activity directly.

“That was exciting to see,” says Robert Gerszten, the director of clinical and translational research for the heart center at Massachusetts General Hospital and another author of the study. The result implies that exercise has complicated, chain-reaction metabolic effects; activity causes actions within cells that release metabolites, which, in turn, act on genes in ways that change your blood levels of fatty acids and blood sugar. These levels of fatty acids and blood sugar then play a role in your risks for heart disease, diabetes and other conditions.

Dr. Lewis cautions that his group’s work is still preliminary. “This is just a chemical snapshot,” static and limited, of a person’s bloodstream after exercise, he says. Even with mass spectrometry, not every type of metabolite can be captured, and the role of some of the metabolites that were uncovered remains unknown. But the experiment does reinforce the lesson, which we all know whether we heed it or not, that the human body needs to move.

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